Valeria Giandomenico Ph.D

Assoc. Professor
Department of Medicine
Uppsala University Hospital

Professional Experience

• 2010 - Assoc. Professor, Experimental Endocrine Oncology Dept of Medical Sciences Uppsala University, Sweden
• 2008-2010 Senior Scientist, IMV, Endocrine Oncology, Uppsala University, Sweden
• 2002-2008: Research Associate, Clinical Immunology, Uppsala University, Uppsala, Sweden
• 2000-2002: Post-Doctoral Fellow, Ludwig Institute for Cancer Research, Uppsala, Sweden
• 1997-1999: Research Fellow, NCI, NIH, Bethesda, MD, USA
• 1994-1997: Research Fellow, Laboratory of Virology, Istituto Superiore di Sanitá (ISS), Rome, IT

Education

• 2000:  Ph.D. in Biology, University of Rome (ROMA TRE), Rome, Italy.
• Lab work was performed at the ISS, Rome, Italy and at the NCI, NIH, in Bethesda, MD, USA
• 1994:  Doctorate degree in Biological Science, University of Rome, (La Sapienza), Rome, IT
• 1989:  Scientific Maturity Degree, Liceo Scientifico “Plinio Seniore”, Rome, IT

Additional Courses

• 2008:  Training Course for International PhD Supervisors, Autumn, Uppsala University, Office for Development of Teaching and Learning 
• 2007: Obligatorisk utbildning för handledare på forskarnivå vid vetenskapsområdet för medicin och farmaci, Uppsala University, Uppsala, Sweden
• 2007: International Teacher Training Course Unit of Development of Teaching and Interactive Learning, Uppsala University
• 2005: Analysis of Microarray Expression Data (1.5 ECT Credits) The Linnaeus Centre for Bioinformatics, Uppsala Unniversity
• 1999:  Bio TRAC9 -PCR & Molecular Hybridization Techniques (Two credits) F.A.E.S., N.I.H., Bethesda, MD, USA
• 1996:  Integrins in Oncology Scuola Superiore di Oncologia e Scienze Biomediche, Genova, Italy
• 1994:  Cellular cycle and apoptosis, flow cytometry techniques and molecular biology Scuola Superiore di Oncologia e Scienze Biomediche, Rome, Italy

Specific Technical Skills - Molecular Biology, Cell Biology, Biochemistry

• Protein characterization (SDS-PAGE, Western blot, immunoprecipitation, immunohisto-chemistry, tissue arrays, enzyme assays, acetylation assays, antibody purification)
• RNA isolation, preparation and analysis (Northern blot, RNase protection, Run-on)
• RNA interference
• Genomic DNA isolation, preparation and analysis (Southern blot)
• Recombinant DNA cloning, plasmid isolation
• PCR, RT-PCR, Quantitative Real Time PCR
• Electrophoretic mobility shift assay
• Reporter gene detection assays, promoter analysis
• Cell culture (cell lines and primary cell cultures), cell transfections, virus infections
• Microscopy, immunofluorescence microscopy
• Laser-capture microdissection (LCM) and Immuno-LCM and RNA or protein extraction
• Microarray analysis (Affymetrix) and bioinformatics

Research Interest

• Neuroendocrine tumors with focus on tumor biology
• Identification of novel biomarkers for early diagnosis and prognosis
• Role of microRNAs expression in early tumorigenesis and tumor progression.
• Somatostatin analogues; drug effects and tachyphylaxis mechanisms
• Development of novel therapies

Awards & Grants

• 2010: Erik, Karin och Gösta Selanders Stiftelse
• 2010: Tore Nilsons Foundation for Medical Research
• 2009: Tore Nilsons Foundation for Medical Research
• 2009: Abstract Award during the 43rd Annual Scientific Meeting of the ESCI for outstanding presentation of important scientific work in the field of NETs
• 2008: Tore Nilsons Foundation for Medical Research
• 2002:  Wenner-Gren Foundations Guest Research Fellow Award
• 2001:  Wenner-Gren Foundations Guest Research Fellow Award
• 1997-1999:  The National Institute of Health’s Visiting Fellow Award

Publications

To search for publications by V. Giandomenico, please see reference list.